pKa tuning in quadrupolar-type two-photon ratiometric fluorescent membrane probes.
نویسندگان
چکیده
Two bolaamphiphilic quadrupoles built from a fluorene core conjugated with azine endgroups were designed and successfully used to stain GUV membranes. Their quadrupolar character induces both a shift of the pKa values close to the physiological pH and large two-photon absorption responses (i.e. over 1000 GM for acidic forms). As such they hold promise as ratiometric two-photon pH probes for monitoring slight variations of pH near cell membranes using two-photon excitation in the NIR region.
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عنوان ژورنال:
- Chemical communications
دوره 51 83 شماره
صفحات -
تاریخ انتشار 2015